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About us > Our People > Academic Staff > Dr Dennis TSE
Our People
Dr Henry CHAN | Dr Allen CHEONG | Prof. Pauline CHO | Dr Chi-wai DO | Dr Chea-su KEE | Prof. Carly LAM | Dr Andrew LAM | Dr Thomas LAM | Dr Tina LIAN | Dr Bin LIN | Dr Larry NG | Dr Feng PAN | Dr Patrick TING | Prof. Chi-ho TO | Dr Dennis TSE | Prof. George WOO | Prof. Maurice YAP

Dr Dennis TSE

Dr Dennis Yan-yin TSE
BSc, PhD
Associate Professor

ORCiD 0000-0001-7561-9121
Author ID (Scopus) 23478668500

Biographical Sketch

Dr Dennis Tse obtained his BSc Optometry and PhD degrees from The Hong Kong Polytechnic University (PolyU). His early research focused on the modulation of refractive development by optical defocus in animal models. The basic scientific discoveries were later translated into clinical applications in the form of contact lenses and eyeglasses that effectively control myopia progression in children. Upon receiving his PhD, he spent two years in Australia as a postdoctoral fellow as part of a collaborative myopia research project between PolyU and the University of Newcastle. In 2011, he joined the Dept. of Ophthalmology of Baylor College of Medicine in the United States, where he received further postdoctoral training on retinal physiology from Prof. Samuel Miao-Sin Wu. He returned to his alma mater to serve as a Research Assistant Professor in late 2014. He was promoted to Assistant Professor and Associate Professor in 2016 and 2020, respectively. He is currently the subject leader of “Visual Science 4”, and “Management and Prevention of Refractive Error” in the School of Optometry.

Dr Tse’s current research interests include retinal neuroscience, mechanism and treatment of myopia, and the role of autophagy and oxidation in retinal degenerations. His research has been published in international journals including Autophagy, Nature Communications, Scientific Reports, Investigative Ophthalmology and Vision Science, Oxidative medicine and Cellular Longevity, British Journal of Ophthalmology, Experimental Eye Research, and etc. He has been serving as an editorial board member for the journal “Scientific Reports” since 2016. He is currently a member of the department staffing committee of the school, and a member of the registration committee of the Optometrist Board of Hong Kong.

Dr Tse was named the 2012 Loris and David Rich Scholar  by the International Retinal Research Foundation for his research on the pathogenesis of glaucoma. He was awarded a Grand Prize and Gold Medal with Jury's Commendation at the 39th International Exhibition of Inventions of Geneva in 2011, and a Faculty Award in Research and Scholarly Activities (Team) in 2020 for his research on myopia. He was also an awardee of the Endeavour Cheung Kong Research Fellowship, and the Sir Edward Youde Memorial Fellowships in his earlier career. His research has been supported by the Research Impact Fund and General Research Fund from the Research Grants Council of HK, Innovation and Technology Support Programme, and Midstream Research Programme from the Innovation and Technology Commission of HK, as well as Large Equipment Funds from the PolyU.

Dr Tse welcomes young talents to join his research team. Postdoctoral, technical and student positions are available.  

Selected Publications 

  1. Abokyi S, To CH, Lam T, Tse DY. Central role of oxidative stress in age-related macular degeneration: Evidence from review of the molecular mechanisms and animal models. Oxidative medicine and cellular longevity. 2020 Feb 10;2020:7901270.
  2. Lotfi P, Tse DY, Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M. Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy. 2018;14(8):1419-1434.
  3. Zheng H, Tse DY, Tang X, To CH and Lam TC. The interactions between bright light and competing defocus during emmetropization in chicks. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2932-2943.
  4. Shan SW, Tse DY, Zuo B, To CH, Liu Q, McFadden SA, Chun RK, Bian J, Li KK, Lam TC. Integrated SWATH-based and targeted-based proteomics provide insights into the retinal emmetropization process in guinea pig. J Proteomics. 2018 Jun 15;181:1-15.