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About us > Our People > Academic Staff > Dr Henry CHAN
Our People
Dr Henry CHAN | Dr Allen CHEONG | Prof. Pauline CHO | Dr Rachel CHUN | Dr Chi-wai DO | Dr Chea-su KEE | Prof. Carly LAM | Dr Andrew LAM | Dr Thomas LAM | Dr Jeffrey LEUNG | Dr Tina LIAN | Dr Bin LIN | Dr Jessica NEUVILLE | Dr Larry NG | Dr Feng PAN | Dr Ellen TAN | Dr Patrick TING | Prof. Chi-ho TO | Dr Dennis TSE | Prof. George WOO | Prof. Maurice YAP

Dr Henry CHAN

Dr Henry CHAN
PhD PDipOptom FAAO
Associate Professor

ORCiD 0000-0002-8516-4711
Author ID (Scopus) 24774420300

Biographical Sketch

Dr Henry Chan obtained the Professional Diploma in Optometry from the Hong Kong Polytechnic and his PhD degree from The Hong Kong Polytechnic University. He joined as teaching staff in 1997.

Dr Chan is currently Associate Professor and Chief of Optometry Clinic in the School. He has managed the Visual Electrophysiology service of The Optometry Clinic since 1998. 

Dr Chan is an Honorary Associate Professor of the Eye Institute and Department of Anatomy of The University of Hong Kong. Dr. Chan is a Fellow of the American Academy of Optometry. He was Vice-President of the Hong Kong Society of Professional Optometrists during 2003 - 2004.

Dr Chan is widely recognized for his academic and research achievements.  He is the principal investigator of numerous researches on visual electrophysiology.  His studies on new visual electrophysiology, the multifocal electroretinogram, were published in leading journals including the British Journal of Ophthalmology, Investigative Ophthalmology and Visual Science and Vision Research.

Selected Publications

  1. Chu PHW, Li HY, Chin MP, So K, Chan HHL. Effect of Lycium Barbarum (Wolfberry) Polysaccharides on Preserving Retinal Function after Partial Optic Nerve Transection. PLoS ONE. 2013;8(12):e81339.
  2. Li HY, Ruan YW, Kau PW, Chiu K, Chang RC, Chan HHL, So KF. Effect of Lycium Barbarum (wolfberry) on Alleviating Axonal Degeneration after Partial Optic Nerve Transection. Cell Transplant. 2015;24(3):403-17.
  3. Chan HHL, Lam HI, Choi KY, Li SZ, Lakshmanan Y, Yu WY, Chang RCC, Lai J, So KF. Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement. J Ethnopharmacol 2019;236:336-344
  4. Lakshmanan Y, Wong FSY, Yu WY, Li SZC, Choi KY, So KF, Chan HHL. Lycium Barbarum Polysaccharides rescue neurodegeneration in an acute ocular hypertension rat model under pre- and post-treatment Conditions. Invest Ophthalmol Vis Sci 2019;60:2023-2033.
  5. Li ZC, Yu WY, Choi KY, Lam CHI, Lakshmanan Y, Wong FSY, Chan HHL. Subclinical decrease in central inner retinal activity is associated with myopia development in children. Invest Ophthalmol Vis Sci 2017;58:4399-4406.

Selected Grants

  1. Chan HHL(PI), Lam TC. Effectiveness of myopia control by Breath-O correct orthokeratology lenses in different myopia progression groups: A 2-year randomized clinical trial
    Collaborative Research fund (SEED Co. Ltd, Japan)
  2. Chan HHL(PI), Ng LK, Yu WY. Treatment effect of tropical application of low-concentration (0.01%) atropine on the human eye with fast and slow myopia progression rate as classified by electro-retinal responses - A randomized controlled trial.
    Funded by General Research Fund, Research Grants Council, HKSAR
  3. Chan HHL(PI), So KF, Chang RCC, Lai SM, Do CW, Benzie IFF, Leung MCP. Cone rescue in retinitis pigmentosa by the treatment of Lycium barbarum
    Funded by Health and Medical Research Funds, HKSAR
  4. Kee CS, Chan HHL(Co-I), Stell WK. Experimentally induced astigmatism: its effect on myopia development, and its neurobiological basis
    Funded by General Research Fund, Research Grants Council, HKSAR
  5. Chan HHL(PI), Kee CS. Foveal function and peripheral refractive errors in emmetropization
    Funded by General Research Fund, Research Grants Council, HKSAR

Research Insight

In 2006, a new paradigm – slow double-stimulation multifocal electroretinogram (mfERG) – was developed for clinical use, which could bypass the detrimental effect of unclear ocular media (e.g. cataract) to benefit clinicians examining retinal health. Based on this design, I further developed another paradigm for early glaucoma diagnosis. This new method has over 90%  both sensitivity and specificity for differentiating eyes with glaucoma from normal eyes. In 2012, this special measurement was  first used and  has been proven to detect glaucomatous changes at least 4 years before it being detected by the current clinical tests.

Over the same period, I also used mfERG to investigate the myopic eye. The central inner retinal activities recorded using a specific multifocal ERG measurement were significantly correlated with later myopia progression in children. It is, therefore, a potential reference technique to follow the development of juvenile myopia. I believe that this technique can be applied clinically to estimate the refractive errors progression for an individual child.

My research also focuses on the treatment of eye diseases using Lycium Barbarum (LB) which is a commonly used Traditional Chinese Medicine (TCM). One study showed that a 12-month LB treatment was able to preserve vision and retinal structure in Retinitis Pigmentosa (RP) patients. This was  the first study to use a pharmacological approach to RP by applying TCM to delay the progression of heredity retinal degeneration.