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Mr. Chunghim SO | Mr. Dong LIANG | Mr. Milan RAI | Ms. Jing ZHANG | Ms. Shuwen JIA | Ms. Wing Yan LAU | Ms. Yingkun CUI | Ms Jingfang Jennifer BIAN | Mr Shashi Kant CHAUDHARY | Ms Meng CHENG | Mr Ka Wai Jimmy CHEUNG | Mr Kai Yip CHOI | Ms Hang I Christie LAM | Ms Hoi Lam LI | Ms Sonal Aswin VYAS | Mr Kin Ken WAN | Ms Biyue GUO | Ms Li PAN | Ms Qi TAN | Mr Mezbah UDDIN | Mr Bing Yuan KONG | Ms Rong LI | Ms. Yuanyuan LIANG | Ms Anqi LYU | Mr Ying Hon SZE | Ms Qin WANG | Ms Hanyu ZHANG | Ms Wei YANG | Ms Mei ZHAO | Ms Yajing YANG | Ms Fangyu XU | Mr Sung Hei Jimmy TSE | Ms. Seen Hang CHAN


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Mr. Chunghim SO

Mr. Chunghim SO
PhD Student

ORCiD 0000-0002-7439-5741

Title of project:
Effect of NSAID in treating non-proliferative diabetic retinopathy in STZ-induced mice

Synopsis:
Diabetic retinopathy (DR), a diabetes complication related to the eyes, is a medical condition in which retinal damage occurs and could progress to blindness at the late stage. One of the most common features of non-proliferative diabetic retinopathy (NPDR) is capillary occlusion. During occlusion, ischemia and hypoxia could drive the microenvironment into a pro-inflammatory state. Using a mice model of type 1 diabetic induced streptozotozin, this study attempts to administer the tested drugs such as aspirin directly into the eye through intravitreal injection in order to prevent the progression of DR. In addition, visual optokinetic response and intracellular labelling will be used to determine the efficacy of the treatment by observing visual acuity and alpha ganglion cell morphology, respectively. The long-term goal is to develop a new line of drug to benefit patients with diabetic retinopathy.

 

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