Multi-functional Gas Vesicles for Enhanced Cancer Therapy
Recently reported gas vesicles (GVs) have been demonstrated as the first biomolecular acoustic reporters with gene editability and inherent stability. In this innovation, multi-functional GVs are developed for enhanced cancer therapy through the surface modification, endowing it with various properties. Notably, the PEGylated HA-GVs have high tumor-targeting efficacy, enabling it to serve as a molecular ultrasound probe for in vivo tumor detection; whereas lipid-GVs could function as an oxygen carrier that could deliver large quantity of oxygen to the tumor site to alleviate tumor hypoxia. Besides, GVs themselves could facilitate the occurrence of cavitation which can potentially enhance the efficacy of sonodynamic therapy. As such, modified GVs could function as a potent theranostic tool in the future of cancer treatment.