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Seminar - Interfaces, adhesion, and the attachment of tendon to bone by Prof. Guy M. Genin
日期:2016 年 09 月 19 日 ( 星期一)
Time:2:30 pm – 3:30 pm
Venue:EF305

Abstract:

Joining of dissimilar materials is a fundamental challenge in engineering. Nature presents a highly effective solution at the attachment of tendon to bone in the rotator cuff of the shoulder’s humeral head. The natural attachment is far superior to that which exists following healing or surgical repair: the natural attachment does not regrow, and recurrence of tears following surgical repair is as high as 94%. We therefore focus on understanding the adhesion and toughening mechanisms operate across scales in the healthy attachment, and on reconstituting these in healing.

Although much of the basic physiology is still debated, it is clear that hierarchical nanoscale-to-milliscale toughening mechanisms are central to tissue resilience, and that mechanical factors play a central role in developing and sustaining these mechanisms. This talk will focus on statistical mechanics predictions of how randomness of the otherwise highly ordered tendon-to-bone attachment makes the natural attachment resilient, and will conclude with a brief overview of 3D strain mapping techniques we are developing for the purpose of detecting the health of some of these stochastic toughening mechanisms in patients who present with shoulder injuries.

Bio-sketch:

Guy M. Genin studies interfaces and adhesion in nature, physiology, and engineering. He is professor of mechanical engineering and neurosurgery at Washington University in St. Louis (WUSTL), and Changjiang Professor at Xi’an Jiaotong University. Prof. Genin is WUSTL PI for the Center for Engineering Mechanobiology, a major NSF Science and Technology Center collaboration with the University of Pennsylvania. He serves as chief engineer for WUSTL’s Center for Innovation in Neuroscience and Technology and is active in several start-ups. He is co-lead of the NIH/Interagency Modeling and Analysis Group's working group on integrated multiscale biomechanics experiment and modeling, and has served as an editor, guest editor, or associate editor of a number of journals, including PNAS, ACS Biomaterials Science and Engineering, Acta Mechanica Sinica, ASME J Biomech Eng, and J Roy Soc, Interface Focus. Prof. Genin’s training includes B.S.C.E. and M.S. degrees from Case Western Reserve University, S.M. and Ph.D. degrees in solid mechanics from Harvard, and post-doctoral training at Cambridge and Brown. His awards for design, teaching, and research include a Research Career Award from the NIH, the Skalak Medal from the ASME, Professor of the Year from WUSTL, and the Yangtze River Scholar Award from the Chinese Ministry of Education.