Seminar - Structure-based finite strain modelling of the human left ventricle in diastole by Professor X. Y. Luo
Date: 02 August 2012 (Thursday)
Time: 11:00 am – 12:00 pm
Venue: EF305, The Hong Kong Polytechnic University
Finite strain analyses of the left ventricle provide important information on heart function, and have the potential to provide insights into the biomechanics of myocardial contractility in health and disease. Systolic dysfunction is the most common cause of heart failure, and can be treated with evidence-based drug therapies. Abnormalities of diastolic function also contribute to heart failure, however, and are associated with conditions including left ventricular hypertrophy and diabetes. The clinical significance of diastolic abnormalities is less well understood than systolic dysfunction, and specific treatments for diastolic dysfunction are presently lacking. To obtain qualitative and quantitative information on heart function in diastole, we develop an anatomically realistic model of the human left ventricle that uses a structure-based constitutive model along with a rule-based fibre structure. We investigate the sensitivity of this comprehensive model to small changes in the constitutive parameters and to changes in the fibre distribution. We also compare the predictions of this model to similar computational models that employ different constitutive modelling approaches, and to available computational and experimental data on stress and strain distributions in the left ventricle. Our results highlight the need for additional experimental data for both model development and validation.
Xiaoyu Luo graduated from the Xi'an Jiaotong University, China, with BSc in Solid Mechanics, MSc in Applied Mechanics, and PhD in Biofluid Mechanics. From 1992 to 1997, She worked as a post-doc Research Fellow with Professor T J Pedley, FRS, on modelling fluid flow in collapsible tubes at the University of Leeds. From 1997 to 2000, She worked at the Department of Engineering, Queen Mary and Westfield College, before she took up a position at the Department of Mechanical Engineering, University of Sheffield. She joined the school of Mathematics and Statistics at University of Glasgow in 2005. Her current research is on modelling and numerical simulations of flows, fluid-structure interaction, soft tissue mechanics, with applications to physiological problems. She is engaged in several projects including active stress modelling of the human biliary system and its correlation with pain, multi-scale modelling of the heart, vocal folds vibration, dynamic motion of heart valves, flow in collapsible tubes, and nonlinear stress analysis of thick-walled tubes. Prof. Luo is a Fellow of the Institution of Mechanical Engineers, a member of the EPSRC college, and on the editorial boards of several international journals.