Seminar - Probing mechanical principles of cell-nanoparticles interaction by Dr. Xinghua SHI
Date: 19 March 2012 (Monday)
Time: 4:00 pm – 5:00 pm
Venue: BC305, The Hong Kong Polytechnic University
Nanoparticles (NP) such as carbon nanotubes, nanowires, nanofibers, quantum dots and graphene have potential applications for next generation microchips, composites, barrier coatings, biosensors, and drug delivery. Understanding the way cells interact with NP is important for assessing the hazards of NP to human health, for creating safer biomedical diagnostics and therapies, and for regulating occupational and enviromental exposure. In this talk, we will discuss some recent studies on the mechanics of cell-NP interactions, including the mechanics of cellular uptake of NP by receptor-mediated endocytosis and coarse-grained molecular dynamics simulations of complete lipid bilayer segments interacting with NP. The discussions will be organized around the following questions: Why and how does cellular uptake of NP depend on the particle size, shape, aspect ratio and elasticity? In particular, we will discuss the effect of elastic stiffness on cell-particle interactions and how cylindrical one-dimensional nanomaterials such as carbon nanotubes enter cells.
Dr. Xinghua Shi received his B.S. (2001) degree from Department of Mechanics, Peking University, M.S. (2004) degree from Institute of Mechanics, Chinese Academy of Sciences and Ph.D (2010) degree from School of Engineering, Brown University. He joined the Institute of Mechanics, CAS in 2011 after serving a brief appointment at Brown University as a post-doctoral research associate. Dr. Shi’s research focuses on the mechanics of nanomaterials, contact mechanics and cytotoxicity of nanoparticles..