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Detecting sub-clinical abnormal retinal activities caused by early glaucomatous changes and predicting glaucomatous progression


New Electroretinogram Assessment for Early Glaucoma Detection

Glaucoma is a chronic eye disease that shows no symptoms in early stages. Risk factors for developing it include high intra-ocular pressure, high myopia and a family history with glaucoma. To diagnose glaucoma, a standard clinical test called Visual Field testing is usually used. However, it is reported that only after the patient loses about 25% of his retinal neurons can a change be detected.

Recently, the Spectral-domain Optical Coherence Tomography (SD OCT) test is used to measure the thickness of the retinal tissue for glaucoma detection. However, the change of structural thickness is also related to the loss of neurons. Hence, this test cannot be used to detect early changes in glaucoma either. In light of this, PolyU has developed a new protocol of multifocal electroretinogram (mfERG), which can detect glaucomatous damage before the onset of structural changes, and to test the retinal functions that are primarily affected by early glaucoma.

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