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A bone-mimicking, mechanically strong grafting material that facilitates osteogenesis and angiogenesis

Current bone graft materials have exhibited certain therapeutic efficacy. However, determining the tradeoff between processability, mechanical strength and bioactivity of the materials remains a challenging task, which limits their clinical application. Our novel photocrosslinkable nanocomposite which mimics the structure of natural bone is fabricated within 140 seconds under UV at 36°C. The low temperature and organic solvent-free fabrication allows it to be loaded with, preserve and perform long-term release of bioactive molecules, e.g. growth factors, for promoting bone regeneration. Besides, it can activate cell signalling pathways to facilitate osteogenesis and angiogenesis simultaneously while providing optimal mechanical support to the injured area, accelerating the recovery of bone injuries and fractures.

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