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Selected Publications on Cancer Genomics and Bioinformatics

Title Authors
Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia. Scientific Reports, 2015, 5 (10973)
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Lawrence WC Chan, Xihong Lin, Godwin Yung, Thomas Lui, Ya Ming Chiu, Fengfeng Wang, Nancy BY Tsui, William CS Cho, SP Yip, Parco M Siu, SC Cesar Wong, Benjamin YM Yung
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Clinical significance of cytokeratin 20-positive circulating tumor cells detected by a refined immunomagnetic enrichment assay in colorectal cancer patients. Clin Cancer Res, 2009;15(3):1005-12
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Wong SC, Chan CM, Ma BB, et al.
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Clinical significance of CDX2-positive circulating tumour cells in colorectal cancer patients. Br J Cancer 2011;104(6):1000-6
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Wong SC, Ng SS, Cheung MT, et al.
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DECODE: An Integrated Differential Co-expression and Differential Expression Analysis of Gene Expression Data. BMC Bioinformatics, 2015, 16:182.
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Thomas WH Lui, Nancy BY Tsui, Lawrence WC Chan, Cesar SC Wong, Parco MF Siu, Benjamin YM Yung
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Acute treatment of resveratrol alleviates doxorubicin-induced myotoxicity in aged skeletal muscle through SIRT1-dependent mechanisms. Journal of Gerontology: Biological Sciences, in press
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Sin TK, Tam BT, Yu AP, Yung BY, Yip SP, Chan LW, Wong CS, Rudd JA, and Siu PM
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Selected Publications on Complex Diseases and Microbial Infections

Title Authors
Identification of the WNT7B gene provides insights into the mechanism underlying myopia development. Nat Commun 2015; 6: 6689.
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Miyake M, Yamashiro K, Tabara Y, Suda K, Morooka S, Nakanishi H, Khor CC, Chen P, Qiao F, Nakata I, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, the Nagahama Study Group, Meguro A, Kusuhara S, Polasek O, Hayward C, Wright AF, Campbell H, Richardson AJ, Schache M, Takeuchi M, Mackey DA, Hewitt AW, Cuellar G, Shi Y, Huang L, Yang Z, Leung KH, Kao PY, Yap MK, Yip SP, Moriyama M, Ohno-Matsui K, Mizuki N, MacGregor S, Vitart V, Saw SM, Tai ES, Wong TY, Cheng CY, Baird PN, Yamada R, Matsuda F, Yoshimura N
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Genetic susceptibility to refractive error: association of vasoactive intestinal peptide receptor 2 (VIPR2) with high myopia in Chinese. PLoS One 2013; 8: e61805
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Yiu WC, Fung WY, Ng PW, Yap MK, Yip SP
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Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice. Pflugers Arch 2015; 467: 2555-69.
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Tam BT, Pei XM, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM
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Autophagic adaptation is associated with exercise-induced fibre-type shifting in skeletal muscle. Acta Physiol 2015; 214: 221-36.
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Tam BT, Pei XM, Yu AP, Sin TK, Leung KK, Au KK, Chong JT, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM
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Genetic algorithm supported by graphical processing unit improves the exploration of effective connectivity in functional brain imaging. Front Comput Neurosci 2015; 9: 50.
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Chan LW, Pang B, Shyu CR, Chan T, Khong PL
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PubMed-supported clinical term weighting approach for improving inter-patient similarity measure in diagnosis prediction. BMC Med Inform Decis Mak 2015; 15: 43.
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Chan LW, Liu Y, Chan T, Law HK, Wong SC, Yeung AP, Lo KF, Yeung SW, Kwok KY, Chan WY, Lau TY, Shyu CR.
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The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes. Biochem Biophys Res Commun 2014; 443: 628–34.
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Kang YL, Saleem MA, Chan KW, Yung BY, Law HK
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A novel selectable ISL-1 positive progenitor cell reprogrammed to expandable and functional smooth muscle cells. Stem Cells 2016; 34: 1354-68.
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Turner EC, Huang CL (co-first author), Sawhney N, Govindarajan K, Clover AJ, Martin K, Browne TC, Whelan D, Kumar AH, Mackrill JJ, Wang S, Schmeckpeper J, Stocca A, Pierce WG, Leblond AL, Cai L, O'Sullivan DM, Buneker CK, Choi J, MacSharry J, Ikeda Y, Russell SJ, Caplice NM.
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Disabled-2 is required for efficient haemostasis and platelet activation by thrombin in mouse. Arterioscler Thromb Vasc Biol 2014; 34: 2404-12.
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Tsai HJ, Huang CL (co-first author), Huang DY, Lin CC, Cooper JA, Cheng JC, and Tseng C-P
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Detection of methicillin-resistant Staphylococcus aureus using a gold nanoparticle-based colourimetric polymerase chain reaction assay. Biosens Bioelectron 2014, 53: 105-11.
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Chan WS1, Tang BS, Boost MV, Chow C, Leung PH
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Ultrasensitive detection of E. coli O157:H7 with biofunctional magnetic bead concentration via nanoporous membrane based electrochemical immunosensor. Biosens Bioelectron 2013, 41: 532-7
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Chan KY, Ye WW, Zhang Y, Xiao LD, Leung PH, Li Y, Yang M
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Bacterial internalization, localization and effectors shape the epithelial immune response during Shigella infection. Infect Immun 2015; 83: 3624-37.
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Lippmann J, Gwinner F, Rey C, Tamir U, Law HK, Schwikowski B, Enninga J
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An upstream truncation of furA-katG operon confer high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance associated mutations. Antimicrob Agents Chemother 2014; 58: 6093-100.
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Siu GK, Yam WC, Zhang Y, Kao RY.
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Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong. PLoS One 2015; 10: e0139728.
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Siu GK, Chen JH, Ng TK, Lee RA, Fung KS, To SW, Wong KC, Cheung S, Wong IW, Tam MM, Lee SS, Yam WC.
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Selected Publications on Healthy Aging: Dietary, Environmental and Lifestyle Influences

Title Authors
Endogenously elevated bilirubin modulates kidney function and protects from circulating oxidative stress in a rat model adenine-induced kidney failure. Scientific Reports 2015 (Oct 26; doi: 10.1038/srep15482
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Boon AC, Lam AK, Goplan V, Benzie IF, Briskey D, Coombes JS, Fassnet RG, Bulmer AC
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The comet assay as a tool for human biomonitoring studies – The ComNet project. Mutation Research-Reviews in Mutation Research 2014; 759: 27-39
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Collins A, Koppen G, Valdiglesias V, Dusinska M, Kruszewski M, Møller P, Rojas E, Dhawan A, Benzie I, Coskun E, Moretti M, Speit G, Bonassi S; for the ComNet project
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Effects of single dose and regular intake of green tea (Camellia sinensis) on DNA damage, DNA repair and heme oxygenase -1 expression in a randomised controlled human supplementation study. Molecular Nutrition & Food Research 2014;58:1379-83
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Ho CK, Choi SW, Siu PM, Benzie IFF
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Plasma allantoin measurement by isocratic liquid chromatography with tandem mass spectrometry: method evaluation and application in oxidative stress biomonitoring. Clinica Chimica Acta 2013;424:237-244
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Chung WY, Benzie IFF
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Comparison of catechin profiles in human plasma and urine after single dosing and regular Intake of green tea. British Journal of Nutrition 2013;109:2199-2207
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Fung ST, Ho C, Choi SW, Chung WY, Benzie IFF
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Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control and complication development in Type 2 diabetes patients. Free Radical Biology and Medicine 2012; 53: 60-63
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Choi SW, Yeung VT, Benzie IFF
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Selected Publications on Applications of Radiation Science in Cancer

Title Authors
A comparison of two systems of patient immobilization for prostate radiotherapy. Radiation Oncology 2014; 9: 29 (DOI: 10.1186/ 1748-717X-9-29)
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White P, Chui KY, Lee CS, Lee WC, Ng HM, Yik SC
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Mammographic breast density in Chinese women: spatial distribution and autocorrelation patterns. 2015. PLoS One 2015; 10: e0136881 (DOI:10: e0136881)
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Lai CWK, Law HKW
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A longitudinal study on the radiation-induced thyroid gland changes after external beam radiotherapy of nasopharyngeal carcinoma. Thyroid 2011; 21: 19-23 (DOI: 10.1089/thy.2010.0229)
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Lin ZX, Wu VWC, Lin J, Feng HT, Chen, LH.
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A comparison of the diagnostic accuracy and reliability of subjective grading and computer-aided assessment of intranodal vascularity in differentiating metastatic and reactive cervical lymphadenopathy. Ultraschall Med 2016; 37: 63-67 (DOI: 10.1055/s-0034-1384939)
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J Lam, M Ying, SY Cheung, KH Yeung, PH Yu, HC Cheng, AT Ahuja.
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Ultrasound evaluation of carotid atherosclerosis in post-radiotherapy nasopharyngeal carcinoma patients, type 2 diabetics, and healthy controls. Ultraschall Med. 2015 Apr 1. [Epub ahead of print] (DOI: 10.1055/s-0034-1399293)
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Yuan C, Wu VW, Yip SP, Kwong DL, M Ying
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Selected Publications on Imaging Research in Metabolic and Vascular Diseases

Title Authors
Randomized Double-blinded Comparison of Norepinephrine and Phenylephrine for Maintenance of Blood Pressure during Spinal Anesthesia for Cesarean Delivery. Anesthesiology 2015; 122: 736-45
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Ngan Kee WD, Lee SWY, Khaw KS, Ng FF
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Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. PLoS ONE 2014 Nov 20;9(11):e113520
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Kang YL, Saleem MA, Chan KW, Yung BY, Law HKW
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A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome. Scientific Reports 2015 Jul 10; 5:10179. doi: 10.1038/srep10179
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Wong KL, Lai YM, Li KW, Lee KF, Ng TB, Cheung HP, Zhang YB, Lao L, Wong RN, Shaw PC, Wong JH, Zhang ZJ, Lam JK, Wencai YE, Sze SC
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Predictors of the extent of carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma. PLOS1. 2014 Dec 31;9(12):e116284. doi: 10.1371/journal.pone.0116284
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Yuan C, Wu VWC, Yip SP, Kwong DLW, Ying MTC
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Haemodynamic effects from aortocaval compression at different angles of lateral tilt in non-labouring term pregnant women. Br J Anaesth 2012; 109: 950-6
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Lee SWY, Khaw KS, Ngan Kee WD, Leung TY, Critchley LAH.
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