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Dr Danyue Zhao Daisy
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Dr Zhao Danyue, Daisy

Assistant Professor

Research Overview

We are interested in studying the interactions between bioactive phytochemicals and gut microbiota, and the novel approaches to extend the bioefficacy of phytochemicals in disease management.

Education and Academic Qualifications

  • PhD, The University of Hong Kong
  • Bachelor (Hons.), Hong Kong Baptist University
  • Postdoctoral Associate, Rutgers - The State University of New Jersey, New Brunswick

Academic and Professional Experience

Academic Membership

  • Council Member, Hong Kong Society of Mass Spectrometry (HKSMS)
  • Member of The American Society for Nutrition (ASN)
  • Member of The Metabolomics Society
  • Member of The Institute of Food Technologists (IFT) 
  • Member of The International Society for Nutraceuticals and Functional Foods

Academic Services (Editorial)

  • Associate Editor, Food Safety and Health (on Wiley)
  • Associate Editor, Food Safety and Health (forthcoming - Summer 2023, on Wiley)
  • Reviewer Editor, Frontiers in Nutrition (Nutrition and Microbes)
  • Guest Associate Editor, Nutrients

Research Interests

  • Polyphenols
  • Phytonutrients
  • Gut Microbiota
  • Probiotics
  • Metabolomics
  • Mass Spectrometry
  • Natural Product Chemistry
  • Food Chemistry
  • Precision Nutrition

Achievements

  • Metabolomics Society Early Career Travel Award - Metabolomics 2024.
  • Outstanding Contribution Award, 6th International Symposium on Phytochemicals in Medicine and Food 2022.
  • The Best Presentation Award, Virtual Podium Asia Pacific 2021 - Proteomics, Metabolomics and Lipidomics.
  • American Society for Nutrition (ASN) Postdoctoral Research Award - Nutrition 2019.
  • ASN Travel Award-Dietary Bioactive Component Research Interest Section - Nutrition 2019.
  • Metabolomics Society Early Career Travel Award - Metabolomics 2018. 
  1. Yang, Y., Lee, P.-K., Wong, H.-C., & Zhao, D.* (2024). Oral supplementation of Gordonibacter urolithinfaciens promotes ellagic acid metabolism and urolithin bioavailability in mice. Food Chemistry 437, 137953. (*Corresponding author) (IF= 8.8)
  2. Zhang, F., Lo, E.K.K., Chen, J., Wang, K., Felicianna, Ismaiah, M.J., Leung, H.K.M., Zhao, D.*, Lee, J.C.Y., El-Nezami, H.* (2024). Probiotic mixture ameliorates diet-induced MASLD/MASH murine model through the regulation of hepatic lipid metabolism and gut microbiome. Journal of Agricultural and Food Chemistry 72, 15, 8536–8549. (*Corresponding author) (IF=6.3)
  3. Shi, B., Wang, H., Nawaz, A., Khan, I. A., Wang, Q., Zhao, D., & Cheng, K. W.* (2024). Dual functional roles of nutritional additives in nutritional fortification and safety of thermally processed food: Potential, limitations, and perspectives. Comprehensive Reviews in Food Science and Food Safety, 23, 1-28. (IF= 14.8)
  4. Chan, Y.-T., Huang, J., Wong, H.-C., Li, J., & Zhao, D.* (2023). Metabolic fate of black raspberry polyphenols in association with gut microbiota of different origins in vitro. Food Chemistry 404 Part B, 134644. (*Corresponding author) (IF= 8.8)
  5. Lo, E.K.K., Wang, X., Lee, P.K., Wong, H.C., Lee, J.C.Y., Gómez-Gallego, C., Zhao, D.*, El-Nezami, H. and Li, J.* (2023). Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches. Computational and Structural Biotechnology Journal 21, 1785- 1796. (*Corresponding author) (IF=6.0)
  6. Lu, Z., Chan, Y.-T., Lo, K., Wong, V. W.-S., Ng, Y.-F., Li, S.-Y., Ho, W. W., Wong, M.-S.*, & Zhao, D.* (2021). Levels of polyphenols and phenolic metabolites in breastmilk and its associations with plant-based food intake in Hong Kong lactating women. Food & Function 12, 12683-12695. (*Corresponding author) (IF=6.1)
  7. Yuan, B., Zhao, D.*, Lyu W., Yin Z., Kshatriya, D., Bello, N.T., Simon, J.E., & Wu, Q.* (2021). Development and validation of a micro-QuEChERS method with high-throughput enhanced matrix removal followed with UHPLC-QqQ-MS/MS for analysis of raspberry ketone-related phenolic compounds in adipose tissues. Talanta 235, 122716. (*Corresponding author) (IF= 6.556)
  8. Westfall, S., Caracci F., Zhao D., Wu, Q.L., Frolinger, T., Simon, J.E., Pasinetti, G.M. (2021). Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promot-ing resilience to stress-induced anxiety-and depressive-like behaviors. Brain, Behavior, and Immunity 91, 350-368. (IF= 19.227)
  9. Zhao, D., Yuan, B., Kshatriya, D., Polyak, A., Simon, J.E., Wu, Q.L. & Bello, N.T. (2020). Influence of diet-induced obesity on the bioavailability and metabolism of raspberry ketone (4-(4-hydroxyphenyl)-2-butanone) in mice. Molecular Nutrition and Food Research 64, 1900907. (IF=6.575)
  10. Wang, J., Zhao, D., Tiano, S., Esteban-Fernández, A., Yuan, B., Smith, C., Brathwaite, J., Jlayer, Z., Wu, Q., Simon, J.E., Trageser, K.J., Pasinetti, G.M. (2020). Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress. Translational Psychiatry 10, 183.
  11. Ho, L.(#1); Zhao, D.(#1); Ono, K.; Ruan, K.; Mogno, I.; Tsuji, M.; Carry, E.; Brathwaite, J.; Sims, S.; Frolinger, T.; Westfall, S.; Mazzola, P.; Simon, J.E.; Wu, Q.L.; Faith, J. & Pasinetti, G.M. (2019). Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity. The Journal of Nutritional Biochemistry 64, 170-181.
  12. Zhao, D.; J.; Simon, J.E. & Wu, Q.L. (2019). A Critical Review on Grape Polyphenols for Neuroprotection: Strategies to Enhance Bioefficacy. Critical Reviews in Food Science and Nutrition 4, 597-625.
  13. Ou, J.; Huang, J.; Zhao, D.; Du, B.; Wang, M. (2018). Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats. Food & Function 9, 851-860.
  14. Zhao, D. & Shah, N.P. (2016). Synergistic administration of lactic acid bacteria and black tea enhances polyphenols bioavailability and relieves D-galactose induced oxidative stress in mice via modulating glutathione-related enzymes. The Journal of Nutritional Biochemistry 38, 116 – 124.
  15. Zhao, D. & Shah, N.P. (2016). Synergistic application of black tea extracts and lactic acid bacteria in protecting human colonocytes against oxidative damage. Journal of Agricultural and Food Chemistry 64, 2238–2246.

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