Academic Staff
- Y824-04
- +852 3400 8714
- bun.tsoi@polyu.edu.hk
Research Overview
My research is mainly related to the pharmacological study of herbal medicine and its active compounds in various neurological diseases, such as stroke and depression, using animal and cellular model.
Education and Academic Qualifications
- Master of Science, Jinan University
- Doctor of Medicine, Jinan University
Academic and Professional Experience
- Member of World Federation of Chinese Medicine Societies
- Associate Editor in Neuropharmacology, Frontiers in Pharmacology
Research Interests
Achievements
- Shen J., Chen H., Tsoi B., Wu W., & Li X. Kit combating ischemic stroke and use thereof. WO2019127672A1, CN109954112A
First and corresponding authorship
- Li, X., Gu, X., Zhou, B., Tsoi, B.*, & Li, W. “Tamarind shell extract mitigates D-glucose-induced eye malformations: Restorative actions on key developmental markers in chick embryos and ARPE-19 cells.” Journal of Functional Foods 115 (2024): 106100. (Corresponding author)
- Tsoi, B., Gao, C., Yan, S., Du, Q., Yu, H., Li, P., Deng, J. & Shen, J. “Camellia nitidissima Chi extract promotes adult hippocampal neurogenesis and attenuates chronic corticosterone-induced depressive behaviours through regulating Akt/GSK3β/CREB signaling pathway.” Journal of Functional Foods 95 (2022): 105199.
- Tsoi, B., Chen, X., Gao, C., Wang, S., Yuen, S. C., Yang, D., & Shen, J. “Neuroprotective Effects and Hepatorenal Toxicity of Angong Niuhuang Wan Against Ischemia–Reperfusion Brain Injury in Rats.” Frontiers in pharmacology 10 (2019): 593.
- Tsoi, B., Wang, S., Gao, C., Luo, Y., Li, W., Yang, D., Yang, D. & Shen, J. “Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury.” Toxicology and Applied Pharmacology, 337, (2019): 114613.
- Tsoi, B., Yi, R., Cao, L., Li, S., Tan, R., Chen, M., Li, X., Wang, C., Li, Y., Kurihara, H. & He, R. “Comparing antioxidant capacity of purine alkaloids: A new, efficient trio for screening and discovering potential antioxidants in vitro and in vivo.” Food Chemistry, 176, (2015): 411-419.
- Tsoi, B., He, R., Yang, D., Li, Y., Li, X., Li, W., Abe, K. & Kurihara, H. “Carnosine ameliorates stress-induced glucose metabolism disorder in restrained mice.” Journal of Pharmacological Sciences, 117, (2011): 223-229.
- He, R., Tsoi, B., Lan, F., Yao, N., Yao, X., & Kurihara, H. “Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice.” Chinese Medicine 6 (2011): 38. (Co-first author)
Co-authorship
- Du, Q., Gao, C., Tsoi, B., Wu, M., & Shen, J. “Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB/ERK/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice.” Frontiers in Pharmacology 14 (2024): 1274343.
- Qin, Z., Shi, D., Li, W., Cheng, D., Zhang, Y., Zhang, S., Tsoi, B., Zhao, J., Wang, Z. & Zhang, Z. J. “Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption.” Journal of Neuroinflammation 20.1 (2023): 54.
- Du, Q., Deng, R., Li, W., Zhang, D., Tsoi, B., & Shen, J. “Baoyuan Capsule promotes neurogenesis and neurological functional recovery through improving mitochondrial function and modulating PI3K/Akt signaling pathway.” Phytomedicine, 93, (2021): 153795.
- He, Y., Chen, S., Tsoi, B., Qi, S., Gu, B., Wang, Z., Peng, C., & Shen, J. “Alpinia oxyphylla Miq. and Its Active Compound P-Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions.” Frontiers in cell and developmental biology 8 (2021): 577790.
- Li, W., Feng, J., Gao, C., Wu, M., Du, Q., Tsoi, B., Wang, Q., Yang, D., & Shen, J. “Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis.” Free Radical Biology and Medicine 143 (2019): 70-83.
- Tan, R. R., Li, Y. F., Zhang, S. J., Huang, W. S., Tsoi, B., Hu, D., Wan. X., Yang, X. Wang, Q., Kurihara, H., & He, R. R. “Abnormal O-GlcNAcylation of Pax3 Occurring from Hyperglycemia-Induced Neural Tube Defects Is Ameliorated by Carnosine But Not Folic Acid in Chicken Embryos.” Molecular Neurobiology 54 (2017): 281-294.