DEPARTMENT OF APPLIED BIOLOGY & CHEMICAL TECHNOLOGY 56 Email wing.leung.wong@polyu.edu.hk Qualification BSc (The Hong Kong Polytechnic University) PhD (City University of Hong Kong) ORCID ID 0000-0001-7191-7578 Dr WONG Wing-leung Assistant Professor Research Overview My research interest focuses on the development of small-sized fluorescent binding ligands, which function as sensitive and selective biosensors and/or potent inhibitors targeting the unique nucleic acid structures, such as RNA and DNA G-quadruplexes, as well as the drug target proteins including telomerase, NDM-1 and peptidoglycan glycosyltransferase for chemical biology and drug discovery. Representative Publications • Sensors and Actuators B: Chemical, 2023, 376, 132992 • Nucleic Acids Research, 2022, 50, 1829–1848 • European Journal of Medicinal Chemistry, 2022, 236, 114360 • Chemical Engineering Journal, 2022, 446, 136947 • Journal of Applied Microbiology, 2022, 133, 2167–2181 • Journal of Medicinal Chemistry, 2021, 64, 2125–2138 • Journal of the Science of Food and Agriculture, 2021, 101, 5163–5171 • Sensors and Actuators B: Chemical, 2020, 314, 128075 • Bioorganic Chemistry, 2020, 99, 103821 • Chemical Communications, 2020, 56, 15016–15019 Patents • US Patent: US9637384B2 • US Patent: US9583711B2 • US Patent: US8318498B2 G-quadruplex DNA (G4-DNA) structure selective fluorescent ligands for anticancer study and a model of molecular interaction for the ligand with the drug target
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