As one of the first ten joint laboratories in the Greater Bay Area (GBA), the Guangdong-Hong Kong-Macau Joint Laboratory of Environmental Pollution Processes and Control unveiled its plaque on 19 December 2019 in Guangzhou. The joint laboratory was a venture led by the Guangzhou Institute of Geochemistry (GIG) of the Chinese Academy of Sciences (CAS) in collaboration with The Hong Kong Polytechnic University and the Guangdong Institute of Eco-environmental Science and Technology, with Prof. Ping’an PENG (Professor of GIG and CAS Academician) and Prof. Xiangdong LI (Chair Professor of CEE at PolyU and Associate Dean of FCE) as the co-directors. The establishment of the joint laboratory marks the further integration of research teams and resources in the GBA, and gives a big boost to the large-scale collaborative research to address pressing environmental issues in the region, such as air quality and human health, ecological risks of emerging contaminants in estuarine and coastal environments, environmental quality in city clusters, control and remediation of soil mixed contamination, and disposal of municipal waste and sewage treatment in rural areas.