Research at FAST

45 Representative Publications • The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma. Zhang B, Zhang Y, Zou X , Chan AWH , Zhang R , L e e TKW, L iu H , Lau EYT, Ho NPY, Lai PBS, Cheung YS, To KF, Wong HK, Choy KW, Keng VW, Chow LMC, Chan KKY, Cheng AS, and Ko BC *. Journal of Pathology 2017 , 243: 418-430 • Tetrandrine, an ac tivator of autophagy, induces autophagic cell death via PKC- α inhibition and mTOR- dependent mechanisms. Wong VKW, Zeng W, Chen J, Yao X J, Leung ELH, Wang QQ, Chiu P, Ko BC *, Law BYK*. Front Pharmacol 2017 , 8 (JUN): 351 • Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Mo d i f i c a t i o n s o f Te l ome r a s e ( T ER T ) Ge n e i n Hepatocellular Carcinoma Cells. Zhang B, Chen J, Cheng AS, Ko BC *. PLoS One, 2014 ; 9(1):e84931 • Sirtuin 2 overexpression in hepatocellular carcinoma mediate s ep i t he lial -me s enchymal t ransi t i on of hepatocellular carcinoma via Akt /GSK3 β/β -catenin signaling pathway. Chen J, Chan AW, Chen W, Zhang Z, To KF, Cheng SH, Ng MH, Lai PB, Huang A, Ko BC *. Hepatology. 2013 , 57(6):2287-98 • Sir tuin 1 (S I RT1) is upregulated in a subs et of hepatocellular carcinoma where it is essential for telomeric maintenance and tumor cell growth. Chan J, Zhang B, Wong N, Lo W, To K, Chan A, Ho C, Ng M, Cheng S, Lai P, Ng H, Ling M, Huang A, Cai X, and Ko BC *. Cancer Research, 2011 , 71(12): 4138-49 Patent • Mainland China Patent application (Application number: 201910562893.1) CTCF inhibitors and their applications. Ko BC , Ma C, Cheung YC, Zhang YJ, Chan WC Dr KO Chi Bun Ben Assistant Professor Research Areas Drug discovery and chemical biology; Pathogenesis of hepatocellular carcinoma The research areas of our group include: (1) Phenotypic screenings using automated high content imaging analysis to identify novel molecules with pharmacological activities; (2) Elucidating molecular targets and mode of action of bioactive compounds using chemical biology approach; (3) Elucidating pathogenesis of liver cancer. Qualification BSc (HKU) PhD (HKU) ORCID ID 0000-0003-2027-5899 Department of Applied Biology & Chemical Technology Department of Applied Biology & Chemical Technology