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Dr Danyue Zhao Daisy
PolyU Scholars Hub

Dr Zhao Danyue, Daisy

Assistant Professor

Education and Academic Qualifications

  • PhD, The University of Hong Kong
  • Bachelor (Hons.), Hong Kong Baptist University
  • Postdoctoral Associate, Rutgers - The State University of New Jersey, New Brunswick

Research Overview

We are interested in studying the interactions between bioactive phytochemicals and gut microbiota, and the novel approaches to extend the bioefficacy of phytochemicals in disease prevention.

Academic and Professional Experiences

Academic Membership

  • Member of The American Society for Nutrition (ASN)
  • Member of The Metabolomics Society
  • Member of The Institute of Food Technologists (IFT) 
  • Member of The International Society for Nutraceuticals and Functional Foods

Academic Services (Editorial)

  • Associate Editor, Food Safety and Health (forthcoming - Summer 2023, on Wiley)
  • Reviewer Editor, Frontiers in Nutrition (Nutrition and Microbes)
  • Guest Associate Editor, Frontiers in Nutrition 

Research Interests

  • Polyphenols
  • Phytonutrients
  • Gut Microbiota
  • Probiotics
  • Metabolomics
  • Mass Spectrometry
  • Natural Product Chemistry
  • Precision Nutrition


  • Outstanding Contribution Award, 6th International Symposium on Phytochemicals in Medicine and Food 2022. 

  • The Best Presentation Award, Virtual Podium Asia Pacific 2021 - Proteomics, Metabolomics and Lipidomics. 

  • American Society for Nutrition (ASN) Postdoctoral Research Award - Nutrition 2019. 

  • ASN Travel Award-Dietary Bioactive Component Research Interest Section - Nutrition 2019. 

  • Metabolomics Society Early Career Travel Award - Metabolomics 2018. 

  1. Chan, Y.-T., Huang, J., Wong, H.-C., Li, J., & Zhao, D.* Metabolic fate of black raspberry polyphenols in association with gut microbiota of different origins in vitro. Food Chemistry (2023); 404 Part B, 134644. (*Corresponding author)
  2. Lu, Z., Chan, Y.-T., Lo, K., Wong, V. W.-S., Ng, Y.-F., Li, S.-Y., Ho, W. W., Wong, M.-S.*, & Zhao, D.* Levels of polyphenols and phenolic metabolites in breastmilk and its associations with plant-based food intake in Hong Kong lactating women. Food and Function (2021); 12, 12683-12695. (*Corresponding author)
  3. Yuan, B., Zhao, D.*, Lyu W., Yin Z., Kshatriya, D., Bello, N.T., Simon, J.E., & Wu, Q.* Development and validation of a micro-QuEChERS method with high-throughput enhanced matrix removal followed with UHPLC-QqQ-MS/MS for analysis of raspberry ketone-related phenolic compounds in adipose tissues. Talanta (2021); 235; 122716. (*Corresponding author)
  4. Zhao, D.; Yuan, B.; Kshatriya, D.; Polyak, A.; Simon, J.E., Wu, Q.L. & Bello, N.T. (2020). Influence of diet-induced obesity on the bioavailability and metabolism of raspberry ketone (4-(4-hydroxyphenyl)-2-butanone) in mice. Molecular Nutrition and Food Research, 64, 1900907.
  5. Wang, J., Zhao, D., Tiano, S., Esteban-Fernández, A., Yuan, B., Smith, C., Brathwaite, J., Jlayer, Z., Wu, Q., Simon, J.E., Trageser, K.J., Pasinetti, G.M. (2020). Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress. Translational Psychiatry, 10, 183.
  6. Westfall, S., Caracci F., Zhao D., Wu, Q.L., Frolinger, T., Simon, J.E., Pasinetti, G.M. (2020). Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promot-ing resilience to stress-induced anxiety-and depressive-like behaviors. Brain, Behavior, and Immunity, in press (Available online 21 October 2020).
  7. Ho, L.(#1); Zhao, D.(#1); Ono, K.; Ruan, K.; Mogno, I.; Tsuji, M.; Carry, E.; Brathwaite, J.; Sims, S.; Frolinger, T.; Westfall, S.; Mazzola, P.; Simon, J.E.; Wu, Q.L.; Faith, J. & Pasinetti, G.M. (2019). Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity. The Journal of Nutritional Biochemistry, 64, 170-181.
  8. Zhao, D.; J.; Simon, J.E. & Wu, Q.L. (2019). A Critical Review on Grape Polyphenols for Neuroprotection: Strategies to Enhance Bioefficacy. Critical Reviews in Food Science and Nutrition, 4, 597-625.
  9. Carry, E.(#1); Zhao, D.(#1); Faith, J.; Ho, L.; Villani, T.; Patel, H.; Pasinetti, G.M.; Simon, J.E. & Wu, Q.L. (2018). Development and validation of a gas chromatography-triple quadruple mass spectrometry method for quantification of microbial phenolic acid metabolites derived from grape flavanols. Journal of Pharmaceutical and Biomedical Analysis, 159, 374-383.
  10. Zhao, D.; Yuan, B.; Carry, E.; Pasinetti, G.M.; Ho, L.; Faith, J.; Mogno, I.; Simon, J.E. & Wu, Q.L. (2018). Development and validation of an ultra-high performance liquid chromatography/triple quadrupole mass spectrometry method for analyzing microbial-derived grape polyphenol metabolites. Journal of Chromatography B, 1099, 34-45.
  11. Ou, J.; Huang, J.; Zhao, D.; Du, B.; Wang, M. (2018). Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats. Food & Function, 9, 851-860.
  12. Zhao, D. & Shah, N.P. (2016). Synergistic administration of lactic acid bacteria and black tea enhances polyphenols bioavailability and relieves D-galactose induced oxidative stress in mice via modulating glutathione-related enzymes. The Journal of Nutritional Biochemistry, 38, 116 – 124.
  13. Zhao, D. & Shah, N.P. (2016). Synergistic application of black tea extracts and lactic acid bacteria in protecting human colonocytes against oxidative damage. Journal of Agricultural and Food Chemistry,64, 2238–2246.

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