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Dr Wilson C.Y. Lau
PolyU Scholars Hub

Dr Lau Chun-yu Wilson

Associate Professor

Research Overview

My research focuses on structural studies on macromolecular assemblies using state-of-the-art cryo-electron microscopy (cryo-EM). Specifically, my groups is interested in elucidating the structure-function relationship of biological machines and ligand discovery against 'undruggable' targets through rational design. 

Education and Academic Qualifications

  • Honours Bachelor of Science, University of Toronto
  • Doctor of Philosophy, University of Toronto

Research Interests

  • Cryo-electron microscopy (cryo-EM)
  • Structural biology
  • Macromolecular assemblies
  • Structure-based drug design


  1. Yuan, D., Zhang, Y., Lim, K.H., Leung, S.K.P., Yang, X., Liang, Y., Lau, W.C.Y., et al.(2022). Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. J Am Chem Soc., 144, 18494
  2. Li, B., Zeng, Y., Cao, W., Zhang, W., Cheng, L., Yin, H., Wu, Q., Wang, X., Huang, Y., Lau, W.C.Y., et al.(2021). A distinct giant coat protein complex II vesicle population in Arabidopsis thaliana. Nature Plants, 7, 1335
  3. Yu, C., Leung, K.P., Zhang, W., Lai, L.T.F., Chan, Y.K., Wong, M.C., Benlekbir, S., Jiang, L., and Lau, W.C.Y. * (2020). Structural basis of substrate recognition by a small heat shock protein. Nature Communications, 12, 3007
  4. Lai, L.T.F., Yu, C., Wong, J.S.K., Lo, H.S., Benlekbir, S., Jiang, L. and Lau, W.C.Y.* (2020). Subnanomter resolution cryo-EM structure of Arabidopsis thaliana ATG9. Autophagy, 16, 575  
  5. Lai, L.T.F., Ye, H., Zhang, W., Jiang, L. and Lau, W.C.Y. * (2019). Structural biology and Electron Microscopy of the Autophagy Molecular Machinery. Cells, 8, pii: E1627      
  6. Kang, W., Ma, T., Liu, W., Qu, J., Liu, Z., Zhang, H., Shi, B., Fu, S., Ma, J., Lai, L.T.F., He, S., Qu, J., Au, S.W., Kang, B.H., Lau, W.C.Y., et al. (2019). Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nature Communications, 10, 4248
  7. Sy, K.H.S., Ho, L.W.C., Lau, W.C.Y., Ko, H. and Choi, C.H.J. (2018). Morphological Diversity, Protein Adsorption, and Cellular Uptake of Polydopamine-Coated Gold Nanoparticles. Langmuir, 34, 14033
  8. Lau, W.C.Y. #,*, Li, Y., Liu, Z., Gao, Y., Zhang, Q. and Huen, M.S.Y. (2016). Structure of the human dimeric ATM kinase. Cell Cycle, 15, 1117
  9. Roh, S.H., Kasembeli, M., Galaz-Montoya, J.G., Trnka, M., Lau, W.C.Y., Burlingame, A., Chiu, W. and Tweardy, D.J. (2016). Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML-ETO. Journal of Biological Chemistry, 291, 4732
  10. Lau, W.C.Y. #,*, Li, Y., Zhang, Q. and Huen, M.S.Y. (2015). Molecular architecture of the Ub-PCNA/Pol eta complex bound to DNA. Scientific Reports, 5, 15759
  11. Kasembeli, M., Lau, W.C.Y., Roh, S., Eckols, Frydman, J., Chiu, W. and Tweardy, D.J. (2014). Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin.  PLOS Biology, 12(4):e1001844

  12. Lau, W.C.Y. # and Rubinstein, J.L. (2013). Single particle electron microscopyMethods inMolecular Biology, 955, 401

  13. Lau, W.C.Y. # and Rubinstein, J.L. (2012). Subnanometer-resolution structure of the intact T. thermophilus H+-driven ATP synthase.           
    Nature, 481, 214

  14. Lau, W.C.Y. # and Rubinstein, J.L. (2009). Structure of intact Thermus thermophilus V-ATPase by cryo-EM reveals organization of the membrane-bound V(O) motor. PNAS107, 1367

  15. Lau, W.C.Y. #, Baker, L.A. and Rubinstein, J.L. (2008). Cryo-EM structure of the yeast ATP synthase. Journal of Molecular Biology, 382, 1256

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