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Dr William CS Tai
Open Platform for University Scholars

Dr Tai Chi-shing, William

Research Assistant Professor

Education and Academic Qualifications

  • Doctor of Philosophy in Biology, Hong Kong University of Science and Technology

Research Overview

The major focuses of our lab are: (1) pre-clinical development of anti-cancer and anti-inflammatory therapeutics from natural compounds and probiotics; (2) functional role of exosomes in molecular pathogenesis
of cancer and inflammatory diseases; and (3) BK polyomavirus in renal transplantation and outcomes.

Academic and Professional Experiences

  • Assoicate Editor (Frontiers in Pharmacology)

Research Interests

  • Cancer Therapy
  • Probiotics
  • Cellular Immunotherapy
  • Drug Development
  • Inflammatory Bowel Disease

Achievements

  1. Lee MML, Chan BD, Wong WY, Leung TW, Qu Z, Huang J, Zhu L, Lee CS, Chen S and Tai WCS* (2020) Synthesis and Evaluation of Novel Anticancer Compounds Derived from the Natural Product Brevilin A. ACS Omega, 5 (24):14586–14596
  2. Lee MML, Chan BD, Wong WY, Qu Z, Chan MS, Leung TW, Lin Y, Mok DK, Chen S and Tai WCS* (2020) Anti-cancer Activity of Centipeda minima Extract in Triple Negative Breast Cancer via Inhibition of AKT, NF-κB, and STAT3 Signaling Pathways. Frontiers in Oncology, 10:491
  3. Chan BD, Wong G, Jiang Q, Lee MML, Wong WY, Chen F, Wong WT, Zhu L, Wong FK and Tai WCS* (2020) Longitudinal study of BK Polyomavirus outcomes, risk factors, and kinetics in renal transplantation patients. Microbial Pathogenesis, 142:104036
  4. Chan BD, Wong WY, Lee MML, Cho, WCS, Yee BK, Kwan YW and Tai WCS* (2019) Exosomes in inflammation and inflammatory disease. Proteomics, 19(8), e1800149
  5. Zhang M, Lee MML, Ye W, Wong WY, Chan BD, Chen S, Zhu L, Tai WCS* and Lee CS (2019) Total Synthesis-Enabled Systematic Structure-Activity Relationship Study for Development of a Bioactive Alkyne-Tagged Derivative of Neolaxiflorin L. The Journal of Organic Chemistry, 84(11):7007-16
  6. Zhu L, Ma W, Zhang M, Lee MML, Wong WY, Chan BD, Yang Q, Wong WT, Tai WCS* and Lee CS (2018) Scalable Synthesis Enabling Multilevel Bio-Evaluations of Natural Products for Discovery of Lead Compounds. Nature Communications. DOI: 10.1038/s41467-018-03546-9. 
  7. Wong WY, Lee MML, Chan BD, Ma VWS, Zhang W, Yip TTC, Wong WT and Tai WCS* (2017) Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling. Oncotarget 8(50):87401-14.
  8. Li H, Xie C, Lan R, Zha S, Chan CF, Wong WY, Ho KL, Chan BD, Luo Y, Zhang JX, Law GL, Tai WCS*, Bünzli JCG and Wong KL (2017) A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations. Journal of Medicinal Chemistry. 60(21):8923-32.
  9. Wong WY, Lee MML, Chan BD, Kam RKT, Zhang G, Lu AP and Tai WCS* (2016) Proteomic profiling of dextran sulfate sodium induced acute ulcerative colitis mice serum exosomes and their immunomodulatory impact on macrophages. Proteomics 16(7):1131-45.
  10.  Tai WCS, Wong WY, Lee MML, Chan BD, Lu C and Hsiao WLW (2016) Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the ApcMin/+mouse model. Proteomics 16(10):1557-69.

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