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Education and Academic Qualifications

  • Bachelor of Science in Medicinal Chemistry, China Pharmaceutical University
  • Master of Science in Molecular Chemistry, Ecole Polytechnique
  • Doctor of Philosophy in Chemistry, Ecole Polytechnique
  • Massachusetts Institute of Technology

Professional Qualifications

  • Licensed Pharmacist (China)
  • Registered Pharmacist (Australia)

Research Overview

The research in our group focuses on drug discovery as well as related topics in organic chemistry and molecular pharmacology.

Academic and Professional Experiences

  • American Chemical Society
  • Chinese Chemical Society

Research Interests

  • Drug Discovery
  • Synthetic Organic Chemistry and Catalysis
  • Mechanism of Drug Action

Achievements

  • 2019 Global Innovation Award, TechConnect World Innovation Conference & Expo
  • 2019 Honorary KTP Visiting Fellowship, University of Technology, Sydney
  • 2014-2015 Faculty Early Career Research Award, University of Newcastle
  • 2009-2010 EDX Postdoctoral Research Fellowship, Ecole Polytechnique
  • 2005-2008 EGIDE Postgraduate Research Fellowship, French Ministry of Foreign Affairs
  • N-Substituted oseltamivir derivatives with antimicrobial activity (WO2020259471A1);
  • Compounds with antimicrobial activity (WO2020001321A1, CN112638909A);
  • Compounds with antimicrobial activity (WO2019138323A1, EP3737664A1, JP2021510143A, US20200347010A1, CN111971271A)
  1. Ye J, Chu AJ, Harper R, Chan ST, Shek TL, Zhang Y, Ip M, Sambir M, Artsimovitch I, Zuo Z, Yang X, Ma C. (2020) Discovery of Antibacterials that Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors. Journal of Medicinal Chemistry 63, 7695–7720. (Supplementary Journal Cover)
  2. Liu Y, Lam LY, Ye J, Blanchard N, Ma C. (2020) DABCO‐promoted diaryl thioether formation by metal‐catalyzed coupling of sodium sulfinates and aryl iodides. Advanced Synthesis & Catalysis 362, 2326-2331. (Highlighted by Organic Process Research & Development: "Some Items of Interest to Process R&D Chemists and Engineers" 2020, 24, 6, 885–896.)
  3. Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Zhang Y, Ip M, Chan PKS, Blanchard N, Hanquet G, Zuo Z, Yang X, Ma C. (2019) Nusbiarylins, a New Class of Antimicrobial Agents: Rational Design of Bacterial Transcription Inhibitors Targeting the Interaction between the NusB and NusE Proteins. Bioorganic Chemistry 92, 103203.
  4. Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Barua N, Zhang Y, Ip M, Chan PKS, Blanchard N, Hanquet G, Zuo Z, Yang X, Ma C. (2019) Design, synthesis and biological evaluation of antimicrobial diarylimine and –amine compounds targeting the interaction between the bacterial NusB and NusE proteins. European Journal of Medicinal Chemistry 178, 214–231.
  5. Yang X, Luo MJ, Yeung ACM, Lewis PJ, Chan PKS, Ip M, Ma C. (2017) First-In-Class Inhibitor of Ribosomal RNA Synthesis with Antimicrobial Activity against Staphylococcus aureusBiochemistry 56, 5049–5052.
  6. Ma C, Yang X, Lewis PJ. (2016) Bacterial Transcription Inhibitor of RNA Polymerase Holoenzyme Formation by Structure-Based Drug Design: From in Silico Screening to Validation. ACS Infectious Diseases 2, 39–46.
  7. Ma C, Yang X, Lewis PJ. (2016) Bacterial transcription as a target for antibacterial drug development. Microbiology and Molecular Biology Reviews 80, 139–160.
  8. Ma C, Letort A, Aouzal R, Wilkes A, Maiti G, Farrugia LJ, Ricard L, Prunet J. (2016) Cascade Metathesis Reactions for the Synthesis of Taxane and Isotaxane Derivatives. Chemistry - A European Journal 22, 6891–6898.
  9. Ma C, Mobli M, Yang X, Keller A, King G, Lewis PJ. (2015) RNA polymerase-induced remodelling of NusA produces a pause enhancement complex. Nucleic Acids Research 43, 2829–2840.
  10. Letort A, Aouzal R, Ma C, Long DL, Prunet J. (2014) Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis. Organic Letters 16, 3300–3303.

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