Theme Co-ordinator: Dr Mo YANG
This thematic research area aims to apply engineering principles and tools to study the fundamental problems in cellular and molecular scales, enabling the understanding of cellular behavior from molecular-level interactions, elucidating of the cellular and molecular mechanisms underlying a broad spectrum of diseases, and tackling the human health-related challenges. We are dedicated to research fields involving cellular mechanics, cell micro-environment, cellular electrophysiology, biomaterials, nanotechnology for theranostics, imaging-guided stem cell therapy, and regenerative medicine.
The specific research areas are listed below:
- To study the influence of mechanical forces on gene expression by changing nuclear mechanics and epigenetics with applications in cancer, stem cells, and immune responses.
- To identify and to understand the niche factors that govern stem cells fate, and drive them towards osteoblastic and/or chondrogenic lineages for tissue repair.
- To study ion channels in reproductive, airway and bone health and diseases, and in particular the development of ion channels into molecular targets for biomedical engineering approaches in the diagnosis/treatment of related human diseases.
- To develop microscale and nanoscale technologies with the ultimate goal of generating tissue-engineered organs and controlling cell behaviors for addressing clinical problems.
- To develop nanoparticle based theranostics (therapeutic diagnostics) capable of imaging, drug delivery and monitoring the therapeutic responses in single platform, enabling targeted cancer therapy and stem cell tracking.