Assistant ProfessorDr. Puxiang LAI


Tel: 3400 8900

Office: ST410

ORCID: 0000-0003-4811-2012

Research Interests

Wavefront engineering; Deep-tissue optical focusing, imaging, and control; Photoacoustic/optoacoustic imaging; Ultrasound-modulated optical tomography; Biomedical optical imaging; Biomedical ultrasound; Optical speckles


Dr. Puxiang Lai received his Bachelor of Engineering in Biomedical Engineering from Tsinghua University, China in 2002, Master of Science in Acoustics from the Chinese Academy of Sciences, China in 2005, and PhD in Mechanical Engineering from the Boston University, USA in 2011 under the supervision of Dr Ronald Roy (currently at the University of Oxford) and Dr Todd Murray (currently at the University of Colorado Boulder). After that, Dr. Lai joined Dr Lihong Wang’s Optical Imaging Lab in the Washington University in St. Louis as a Postdoctoral Research Associate, until September 2015 when he became an Assistant Professor in the Interdisciplinary Division of Biomedical Engineering at the Hong Kong Polytechnic University.

Dr Lai’s research has been focusing on the development of novel biomedical imaging, therapy, and manipulation modalities by using sound and light, including (but are not limited to) 1) noninvasive imaging techniques, such as ultrasonic imaging, acousto-optic imaging, photoacoustic/optoacoustic imaging, and fluorescence imaging; 2) focused ultrasound therapy and its real-time monitoring; 3) noninvasive high-resolution optical focusing at depths in tissue; and 4) deep-penetrating optical imaging, sensing, stimulation and control. These studies have thus far fuelled more than 20 top journal publications (including two first-authored in Nature Photonics and Nature Communications, respectively), more than 50 invited or contributing talks at premium institutions, important international conferences, and winning several best paper/poster awards.  Dr Lai has also been invited to give seminars in many famous universities and research institutions, and served as several conference committee members and session chairs, as well as reviewer or editor for more than 20 premium journals. Since joining BME at PolyU, Dr. Lai aims to continue his research on deep-tissue probing and treatment by using light and sound, which has been supported by the Hong Kong Polytechnic University, the Hong Kong Research Grants Council (RGC), and the National Natural Science Foundation of China (NSFC). Most recently, he has been presented the Hong Kong RGC Early Career Award of 2016-2017.

Selected Recent Publication          

([ ] represent equal contribution)

  1. [ Lai, L. Wang, J. W. Tay], and L. V. Wang, “Photoacoustically guided wavefront shaping (PAWS) for enhanced optical focusing in scattering media,” Nature Photonics 9, 126-132, doi:10.1038/nphoton.2014.322 (2015). (IF=38.752)
  2. [Y. Liu, Lai], C. Ma, X. Xu, A. Grabar, and L. V. Wang, “Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light,” Nature Communications 6:5904, doi: 10.1038/ncomms6904 (2015). (IF=12.124)
  3. [J. W. Tay, Lai], Y. Suzuki, and L. V. Wang, “Ultrasonically encoded wavefront shaping for focusing into random media,” Scientific Reports 4, 3918 (2014). (IF=4.258)
  4. [ Lai, Y. Suzuki, X. Xu], and L. V. Wang, “Focused fluorescence excitation with time-reversed ultrasonically encoded light and imaging in thick scattering media,” Laser Physics Letters, 10(7), 075604 (2013). (IF=2.537)
  5. Lai, X. Xu, H. Liu, and L. V. Wang, “Time-reversed ultrasonically encoded optical focusing in biological tissue,” Journal of Biomedical Optics 17(3), 036001 (2012). (IF=2.53)
  6. Lai, X. Xu, H. Liu, Y. Suzuki, and L. V. Wang, “Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media,” Journal of Biomedical Optics 16 (8), 080505 (2011). (IF=2.53)

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