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Dr Wong Siu Hong Dexter

Dr Dexter Siu-hong WONG

Research Assistant Professor

A fearless researcher is enthusiastic about exploring the micro/nanoscopic world that is highly related to our daily life.

Biography

Dr. WONG Siu Hong Dexter joined the Department of Biomedical Engineering at the Hong Kong Polytechnic University in 2020. He received a B.Eng degree in Biomedical Engineering from the Chinese University of Hong Kong (CUHK) in 2015 where he worked on the fabrication and application of micro/nano-optical-patterned structures to regulate cell mechanics. He further received the Ph.D. degree in Biomedical Engineering from CUHK in 2019 and focused his doctoral study on harnessing cell receptor-ligand interactions via tunable nanostructures to regulate cell fates. Dr. Wong’s research interests focus on novel nanomaterial and nano-composite hydrogel to investigate the nano-bio interface and harness ligand-receptor interaction for cellular mechanotransduction, tissue engineering, and immunotherapy. Moreover, he is also interested in exploring nanoprobes for imaging, biosensing, and therapy in the current study, especially viral detection, to address the current COVID-19 pandemic issue. He has published over 30 journal papers with corresponding, first- and co-authorships, including Advanced Materials, Nano Letters, ACS Nano, Advanced Functional Materials, Theranostics, Nature Communications, Journal of the American Chemical Society, Small, Biomaterials, etc. He is also a member of the Royal Society of Chemistry (MSRC).

Dr. Wong is engaged in teaching postgraduate research students on Nanobiotechnology in Biomedical Engineering and undergraduate level courses on Skin-care Technologies, and Biomaterials Science and Engineering.

Research Interests

  • Nanocomposite Hydrogel
  • Smart Nanoprobe & nanoparticle-mediated drug delivery
  • Cellular mechanotransduction
  • Novel Stimuli-Responsive Substrate
  • Nano-bio interaction

Education and Academic Qualifications

  • PhD in Biomedical Engineering, The Chinese University of Hong Kong

  • BEng in Biomedical Engineering, The Chinese University of Hong Kong

Professional Qualifications

  • Member of Royal Society of Chemistry (MRSC)

Academic and Professional Experience

  • Research Assistant Professor, Department of Biomedical Engineering, Faculty of Engineering, the Hong Kong Polytechnic University, Hong Kong, China,  2020 – Current
  • Research Assistant, Department of Biomedical Engineering, Faculty of Engineering, the Chinese University of Hong Kong, Hong Kong, China,  2019 – 2020
  • Visiting Student Researcher, Department of Chemistry, Stanford University, CA, United States,  2018
  • Research Assistant, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore,  2014

Research Output

(a) Biomarker/Viral detection field:

  1. Zhang, Q., Yin, B., Ma, L., Huang, Y., Shao, X., Li, C., Chu, Z., Hao, J., *Wong, S.H.D., *Yang, M., An AIEgen/graphene oxide nanocomposite (AIEgen@GO)-based two-stage “turn-on” nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence. Aggregate, 2022, 3, e195
  2. Yin, B., Ho, W.K.H., Zhang, Q., Li, C., Huang, Y., Yan, J., Yang, H., Hao, J., *Wong, S.H.D., *Yang, M.,  Magnetic-Responsive Surface-Enhanced Raman Scattering Platform with Tunable Hot Spot for Ultrasensitive Virus Nucleic Acid Detection. ACS Appl. Mater. Interface. 2022, 14, 3, 4714–4724
  3. Yin, B., Ni, J., Witherel, C. E., Yang, M., *Burdick, J. A., *Wen, C., *Wong, S.H.D., Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics. Theranostics, 2022, 12(1): 207231 
  4. Lam, C. Y. K., Zhang, Q., Yin, B., Huang, Y., Wang, H., *Yang M., *Wong, S.H.D., Recent Advances in Two-dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection Before and During COVID-19 outbreak. J. Compos. Sci. 2021, 5(7), 190
  5. +Wong, W.K.R., +Wong, S.H.D., *Bian, L. Long-Term Detection of Oncogenic MicroRNA in Living Human Cancer Cells by Gold@ Polydopamine–Shell Nanoprobe. ACS Biomater. Sci. Eng., 2020, 6, 7, 3778–3783.

(b) Nanotechnology for regulation of stem cell behaviors for tissue engineering field:

  1. +Zhang, J., +Wong, S. H. D., Wu, X., Lei, H., Qin, M., Shi, P., *Wang, W., *Bian, L., *Cao, Y. Engineering Photo-responsive Ligand Tethers for Mechanical Regulation of Stem Cells. Adv. Mater. 2021, 33(48): 2105765
  2. Wong, S.H.D., Wong, W.K.R. Lai, N.C.H. Oh, J. Li, Z. Chen, X. Yuan, W. Bian, L., Soft polymeric matrix as a macroscopic cage for magnetically modulating reversible nanoscale ligand presentation. Nano Lett., 2020, 20, 5, 32073216
  3. +Wong, S.H.D., +Yin, B., Lin S., Yang, B., Li, R., Feng, F., Yang, H., Zhang, L., Yang, Z., Li, G., Choi, C. H., Bian, L., Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells, Adv. Funct. Mater., 2019, 29 (8): 1806822
  4. +Kang, H., +Wong, S.H.D., Yan, X., Jung, H.J., King, S.K., Lin, Si., Wei, K., Li, G., Dravid, V., Bian, L., Remote control of multi-Modal nanoscale ligand oscillations regulates stem cell adhesion and differentiation, ACS Nano, 2017, 11(10): 9636–9649
  5. +Wong, S.H.D., +Li, J., Yan, X., Wang, B., Zhang, L., Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells, Nano Lett., 2017, 17 (3): 16851695

 

(c) Nanotechnology for regulation of immune cell behaviors in the immunotherapy field:

  1. +WONG, W. K., +Yin, B., Lam, C. Y. K., *Tan, Z., *Wong, S.H.D. The Interplay Between Epigenetic Regulation and CD8+ T cell Differentiation/Exhaustion for T cell Immunotherapy Front. Cell Dev. Biol. 2022, 9:783227
  2. +WONG, W. K., +Yin, B., Rakhmatullina, A., *Zhou, J., *Wong, S. H. D., Engineering Advanced Dynamic Biomaterials to Optimize Adoptive T-cell Immunotherapy. Eng. Regen. 2021, 2, 70–81
  3. +Kang, H., +Wong, S.H.D. Pan, Q., Li, G. Bian, L., Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages, Nano Lett. 2019, 19(3): 19631975

 

(d) Nanotechnology for regulation of cancer cell behaviors in the cancer therapy field:

  1. +Wong, S. H. D., +Xu X., Chen X., Xin Y., Xu L., Lai C. H. N., Oh J., Wong W. K., Wang X., Han S., You W., Shuai X., Wong N., *Tan Y., *Li D., *Bian L. Manipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and robust tumorigenicity. Nano Lett. 2021, 21, 7, 3225–3236
  1. Hong Kong Medical and Healthcare Device Industries Association Student Research Awards 2018/19
  2. Global Scholarship Programme for Research Excellence for 2018-19, CUHK
  3. Best Poster/Rapid-Fire presenters Award presented by Biomaterial on the occasion of the 2nd International Symposium on Translational Nanomedicine Center of Functional Biomaterial, Sun Yat-sen University, Guangzhou, January 2017
  1. Guest Editor in “Journal of Composite Science” – special issue: Manufacturing, Characterization and Biomedical Applications of Advanced Micro/Nanocomposites
  2. Invited speaker presentation at “2nd Edition of Materials Science & Nanoscience Webinar” held during April 16-17, 2021. Topic: Developing nanomaterials to harness molecular dynamics for biomedical engineering

Biomolecules, Membranes, Cells, International Journal of Molecular Sciences, Gels, Scientific Reports, Nanomaterials, Immunopharmacology and immunotoxicology, and Nano Letters (available on Publons, Web of Science Researcher ID:  AAT-9831-2021)

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