
- Y820-C
- +852 3400 8871
- wing.leung.wong@polyu.edu.hk
- Personal Website
Education and Academic Qualifications
- Bachelor of Science in Chemical Technology, The Hong Kong Polytechnic University
- Doctor of Philosophy, City University of Hong Kong
Research Overview
We are interested in the development of novel and small-sized ligands that can function as fluorescent biosensors and stabilizers targeting the noncanonical nucleic acid secondary structure of DNA and RNA G-quadruplexes, and potent inhibitor targeting bacterial protein targets including NDM-1 and FtsZ for chemical biology study and drug discovery.
Research Interests
Achievements
- US Patent granted: US9637384B2, Wing Leung Wong, Lai To Leung, Liang Zhang, Chi Mei Chow, Haojun Zhu, Lai Fan Lai, Kwok Keung Paul Ho, “Fullerene derivatives and their applications in organic photovoltaics”.
- US Patent granted: US9583711B2, Paul Kwok Keung Ho, Wing Leung Wong, “New conductive and photosensitive polymers”.
- US Patent granted: US8318498B2, Kwok-Yin Wong, Dik-Lung Ma, Wing Leung Wong, Wai-Hong Chung, Fung-Yi Chan, “Luminescent protein staining and method for detecting poly(amino acid) in a mixture”.
- B.-X. Zheng, J. Yu, W. Long, K.H. Chan, A. S.-L. Leung, W.-L. Wong*. Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study. Chemical Communications, 2023, 59, 1415–1433. (Journal Cover) https://doi.org/10.1039/D2CC05945B
- Y.-H. Zhang, X.-H. Huang, W.-L. Wong*, J.-R. Luo, X.-C. Guo, W. Liu, J. Hou, M.-T. She, W.-H. Jiang, N. Sun*, Y.-J. Lu*. A red fluorescent small-molecule for visualization of higher-order cyclic dimeric guanosine monophosphate (c-di-GMP) structure in live bacterial cells and real-time monitoring of biofilm formation on biotic and abiotic surfaces. Sensors and Actuators B: Chemical, 2023, 376, 132992. https://doi.org/10.1016/j.snb.2022.132992
- W. Long, B.-X. Zheng, Y. Li, X.-H. Huang, D.-M. Lin, C.-C. Chen, J.-Q. Hou, T.-M. Ou, W.-L. Wong*, K. Zhang*, Y.-J. Lu*. Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer. Nucleic Acids Research, 2022, 50, 1829–1848. https://doi.org/10.1093/nar/gkac090
- W. Long, B.-X. Zheng, X.-H. Huang, M.-T. She, A.-L. Liu, K. Zhang*, W.-L. Wong*, Y.-J. Lu*. Molecular recognition and imaging of human telomeric G-quadruplex DNA in live cells: a systematic advancement of thiazole orange scaffold to enhance binding specificity and inhibition of gene expression. Journal of Medicinal Chemistry, 2021, 64, 2125–2138. (Journal Cover) https://doi.org/10.1021/acs.jmedchem.0c01656
- J. Jin, J.-Q. Hou, W. Long, X. Zhang, Y.-J. Lu, D. Li, K. Zhang, W.-L. Wong*. Synthesis of fluorescent G-quadruplex DNA binding ligands for the comparison of terminal group effects in molecular interaction: phenol versus methoxybenzene. Bioorganic Chemistry, 2020, 99, 103821. https://doi.org/10.1016/j.bioorg.2020.103821
- B-X. Zheng, W. Long, Y.-H. Zhang, X.-H. Huang, C.-C. Chen, D.-X. Zhong, M.-T. She, Z.-X. Chen, D.-P. Cai, Y.-J. Lu*, W.-L. Wong*. Rational design of red fluorescent and selective G-quadruplex DNA sensing probes: the study of interaction signaling and the molecular structural relationship achieving high specificity. Sensors and Actuators: B. Chemical, 2020, 314, 128075. https://doi.org/10.1016/j.snb.2020.128075
- C. Wang, Y.-J. Lu*, S.-Y. Cai, W. Long, Y.-Y. Zheng, J.-W. Lin, Y. Yan, X.-H. Huang, W.-L. Wong*, K. Zhang. Advancing small ligands targeting RNA for better binding affinity and specificity: a study of structural influence through molecular design approach. Sensors and Actuators B: Chemical, 2018, 262, 386–394. https://doi.org/10.1016/j.snb.2018.02.004
- N. Sun, C. Wang, M.-H. Xu, Y.-J. Lu*, Y.-Y. Zheng, Y. Yan, X. L. Guo, J.-Q. Hou, K. Zhang, L. G. Luyt, W.-L. Wong*. The interaction of a structural flexible small molecule with nucleic acid structures: investigation of the origin of fluorescence signal discrimination in sensing and the utilization in live cell imaging. Sensors and Actuators B: Chemical, 2017, 250, 543–551. https://doi.org/10.1016/j.snb.2017.05.018
- Y.-J. Lu*, D.-P. Hu, K. Zhang, W.-L. Wong*. New pyridinium-based fluorescent dyes: a comparison of symmetry and side-group effects on G-quadruplex DNA binding selectivity and application in live cell imaging. Biosensors and Bioelectronics, 2016, 81, 373–381. https://doi.org/10.1016/j.bios.2016.03.012
- Y.-J. Lu*, Q. Deng, J.-Q. Hou, D.-P. Hu, Z.-Y. Wang, K. Zhang, L. G. Luyt, W.-L. Wong*. Molecular engineering of thiazole orange dye: change of fluorescent signaling from universal to specific upon binding with nucleic acids in bioassay. ACS Chemical Biology, 2016, 11, 1019–1029. https://doi.org/10.1021/acschembio.5b00987