- Y830
- +852 3400 8674
- clarence-tt.wong@polyu.edu.hk
ORCID ID
SCOPUS IDEducation and Academic Qualifications
- Bachelor of Science, The Chinese University of Hong Kong
- Doctor of Philosophy, Nanyang Technology University
Research Overview
My research group focuses on using state-of-the-art peptide and protein chemistries to manipulate biological systems, including (1) development of multifunctional antibodies for immunotherapy; (2) chemical manipulation of cell behaviour for cell-based therapeutic development; and (3) chemical modification of functional proteins for diseases detection and treatment
Research Interests
Achievements
- Compounds, compositions and methods for the preparation of peptide/protein conjugates. Li, X., Tung, C. L., Wong, C. T. T. US9752137B2, CN104877982B
- Chu, J. C. H., Chin, M. L., Wong, C. T. T.*, Hui, M.*, Lo, P. C.*, Ng, D. K. P.* One-Pot Synthesis of a Cyclic Antimicrobial Peptide-Conjugated Phthalocyanine for Synergistic Chemo-Photodynamic Killing of Multidrug-Resistant Bacteria. Adv. Therap. 2020, 2000204.
- Chu, J. C. H., Yang, C., Fong, W. P., Wong, C. T. T.*, Ng, D. K. P.* Facile One-Pot Synthesis of Cyclic Peptide-Conjugated Photosensitiser For Targeted Photodynamic Therapy. Chem. Commun. 2020, 55, 11941.
- Wong, C. T. T.*, Chu J. C. H., Ha, S. Y. Y., Wong, R. C. H., Dai, G., Kwong, T. T., Wong, C. H., Ng, D. K. P.* Phthalaldehyde-Amine Capture Reaction For Bioconjugation and Immobilization of Phthalocyanines. Org. Lett. 2020, 22, 7098.
- Zhang, Y., Zhang, Q., Wong, C. T. T., Li, X. Chemoselective Peptide Cyclization and Biocyclization Directly on Unprotected Peptides. J. Am. Chem. Soc. 2019, 141.12274.
- Lee, C. L., Liu, H. Wong, C. T. T., Chow, H. Y. and Li, X. Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches. J. Am. Chem. Soc. 2016, 138, 10477-10484.
- Tung, C. L., Wong, C. T. T., Fung, E. Y. M. and Li, X. Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification. Org. Lett. 2016, 18, 2600-2603.
- Wong, C. T. T., Lam, H. Y., Song, T., Chen, G. and Li, X. Synthesis of Constrained Head-to- Tail Cyclic Tetrapeptides by Imine-Induced Ring-Closing/Contraction Strategy. Angew. Chem. Int. Ed. 2013, 52, 10212-10215.
- Lam, H. Y., Zhang, Y., Liu, H., Xu, J., Wong, C. T. T., Xu, C. and Li, X. Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation. J. Am. Chem. Soc. 2013, 135, 6272-6279.
- Wong. C. T. T., Rowlands, D. K., Wong, C. H., Lo, T. W. C., Nguyen, G. K. T., Li, H, Y., Tam, J. P. Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment. Angew. Chem. Int. Ed. 2012, 51, 5620
